Regular exercise is a proven, powerful and cost-effective intervention for the prevention and treatment of cardiovascular disease, the leading cause of death in both men and women in the United States. Our group uses a combination of in vitro and in vivo approaches to gain a better understanding of the fundamental cellular and molecular mechanisms that underlie exercise-induced cardioprotection in coronary artery disease. Through these experiments, we will identify mechanisms driving exercise-induced improvements in blood flow into ischemic myocardium which subsequently promote enhanced cardiac function. Findings from these studies have the potential to provide insight into new therapeutic targets in coronary artery disease.